Researchers at the University of Warwick discover link between autism and damage to proteins in blood plasma

It is estimated that around one in every 100 people in the UK has ASD, with more boys diagnosed with the condition than girls Emmanuel Fradin for Spectrum

Scientists have developed a blood and urine test that can detect autism in children

Researchers at the University of Warwick said the test, believed to be the first of its kind, could lead to earlier diagnosis of autism spectrum disorders (ASD) in children who could then be given appropriate treatment much earlier in their lives.

ASDs mainly affect a person’s social interaction and communication, with symptoms that can include speech disturbances, repetitive and/or compulsive behaviour, hyperactivity, anxiety, and difficulty adapting to new environments.

As there is a wide range of ASD symptoms, diagnosis can be difficult and uncertain, particularly at the early stages of development.

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It is estimated that around one in every 100 people in the UK has ASD, with more boys diagnosed with the condition than girls.

Scientists said their research found a link between ASD and damage to proteins in blood plasma.

They found the most reliable of the tests they developed was examining protein in blood plasma, which found children with ASD had higher levels of the oxidation marker dityrosine (DT) and certain sugar-modified compounds called advanced glycation end products (AGEs).

Genetic causes are thought to be responsible for around a third of cases of ASD, while the rest are believed to be caused by a combination of environmental factors, mutations, and rare genetic variants. But researchers believe their new tests could reveal yet to be identified causes of ASD.

They also confirmed the previously held belief that mutations of amino acid transporters are a genetic variant associated with ASD.

The Warwick team worked with collaborators at the University of Bologna in
Italy, who recruited 38 children who were diagnosed with ASD along with a
control group of 31 other children between the ages of five and 12. Blood and
urine samples were taken from the children for analysis.

The team discovered there were chemical differences between the two groups. Working with a further collaborator at the University of